Evidence / Kaeberlein et al. · 2005
How the assay substrate affects sirtuin findings
Selected research. Study type, product relevance and limitations are shown separately.
Editorial study summary
- Study type
- Biochemical and yeast mechanism study.
- Product relevance
- Methodological context for interpreting resveratrol and sirtuins.
- Sample or population
- Purified enzyme assays and three yeast strain backgrounds.
- Studied dose
- Not reported in the abstract.
- Duration
- Not reported in the abstract.
- Finding
- Resveratrol affected reactions with fluorescently labelled substrates. The effect was absent with unlabelled peptides. The authors found no detectable effect on Sir2 activity or lifespan in the yeast tests.
- Limitations
- These assays do not establish the effects of dietary resveratrol or supplementation in people.
- Study quality
- The study tested whether the result depended on an artificial assay label. Editorial review was limited to the abstract. No formal risk-of-bias rating was assigned.
- Funding and disclosures
- Funding and conflicts were not verified from the abstract.
The studies discussed here examine ingredients or other formulations. They do not establish results for this DR.MORGAN finished product.