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Science / Ingredient Library

Coenzyme Q10 (ubiquinone)

Ubiquinone is the oxidized form of CoQ10.

Definition and mechanism

Ubiquinone and ubiquinol are the oxidized and reduced forms of coenzyme Q10. Cells interconvert the two as part of electron transfer in mitochondria. The form and formulation matter when comparing studies. The combination shown here contains ubiquinone.

Ingredient identity

Medicinal ingredient
CoQ10 (ubiquinone)
Form
Oxidized coenzyme Q10
Amount in PQQ + CoQ10
100 mg per capsule

Licensed product information

PQQ + CoQ10 · NPN 80151407

Recommended use or purpose

(Provides) An antioxidant.
Helps to maintain and/or support cardiovascular health.

Medicinal ingredients

  • PQQ · 20 mg per capsule
  • CoQ10 (ubiquinone) · 100 mg per capsule

Recommended dose

Adults 18 years and older: one capsule once daily.

Cautions and warnings

Consult a health care practitioner/health care provider/health care professional/doctor/physician prior to use if you are pregnant or breastfeeding.
Consult a health care practitioner/health care provider/health care professional/doctor/physician prior to use if you are taking blood pressure medication.

Health Canada licence record ↗

Selected research

CoQ10 and exercise-related biomarkers

Study type
Double-blind placebo-controlled crossover
Product relevance
Relevant ingredient evidence; different formulation
Finding
The abstract reports lower malondialdehyde at selected measurements versus baseline after supplementation.
Limitations
Biochemical exercise outcomes; small male-only sample. No PQQ. Product formulation and full statistical comparisons not verified; no endurance or cardiovascular-event claim.
Funding and disclosures
Not reported in the abstract reviewed.

Ubiquinone and oxidative-stress markers in athletes

Study type
Randomized, double-blind, placebo-controlled human trial.
Product relevance
Ingredient evidence for oxidized CoQ10, or ubiquinone.
Sample or population
31 trained college athletes, with 17 assigned to ubiquinone and 14 to placebo.
Studied dose
300 mg/day of ubiquinone or placebo.
Duration
12 weeks.
Finding
Plasma ubiquinone rose and red-cell malondialdehyde was lower than with placebo. The reported links between white-cell ubiquinone and glucose-control measures were correlations.
Limitations
Biomarkers and correlations in trained athletes do not establish clinical glucose-control or performance benefits.
Study quality
Small parallel-group trial with biomarker endpoints. Editorial review was limited to the abstract. No formal risk-of-bias rating was assigned.
Funding and disclosures
Funding and conflicts were not verified from the abstract.

Ubiquinone and blood markers after exercise

Study type
Double-blind randomized controlled human trial.
Product relevance
Ingredient evidence for oxidized CoQ10, or ubiquinone, as identified in the paper title.
Sample or population
28 healthy men.
Studied dose
Not reported in the abstract.
Duration
21 days.
Finding
Serum CoQ10 rose with supplementation. Several exercise-related blood markers changed, and post-exercise 25(OH)D3 rose only in the placebo group.
Limitations
The trial measured biochemical responses to exercise. It did not establish a performance or recovery benefit.
Study quality
Controlled trial with an exercise challenge and serial blood sampling. Editorial review was limited to the abstract. No formal risk-of-bias rating was assigned.
Funding and disclosures
Funding and conflicts were not verified from the abstract.

The cited studies cover ingredient, material or formulation evidence. They do not establish outcomes for a finished DR.MORGAN product.

Ubiquinone and exercise capacity in trained men

Study type
Double-blind, placebo-controlled human crossover trial.
Product relevance
Ingredient evidence for ubiquinone, the oxidized form of CoQ10. The trial did not test the DR.MORGAN formula.
Sample or population
11 younger and 8 older trained men.
Studied dose
120 mg/day of ubiquinone or placebo.
Duration
6 weeks of ubiquinone supplementation.
Finding
Serum ubiquinone increased. Maximal oxygen uptake did not improve, time to exhaustion was longer with placebo, and serum malondialdehyde did not change.
Limitations
The sample was small and limited to trained men. Blood exposure did not translate to better exercise performance.
Study quality
Controlled crossover with separate age groups and objective exercise testing. Editorial review was limited to the abstract. No formal risk-of-bias rating was assigned.
Funding and disclosures
Funding and conflicts were not verified from the abstract.

Ubiquinone and glycaemic measures in type 1 diabetes

Study type
Randomized, double-blind, placebo-controlled human trial.
Product relevance
Ingredient evidence for ubiquinone, the oxidized form of CoQ10. The trial did not test the DR.MORGAN formula.
Sample or population
34 patients with type 1 diabetes.
Studied dose
100 mg/day of ubiquinone or placebo.
Duration
3 months.
Finding
Serum CoQ10 increased with ubiquinone. There were no between-group differences in glycaemic measures, insulin dose, hypoglycaemic episodes, cholesterol or reported well-being.
Limitations
The study was small and disease-specific. It does not establish general safety or support changes to diabetes care.
Study quality
Randomized comparison of blood measures, insulin use and patient-reported outcomes. Editorial review was limited to the abstract. No formal risk-of-bias rating was assigned.
Funding and disclosures
Funding and conflicts were not verified from the abstract.

Ubiquinone in a diabetic polyneuropathy trial

Study type
Randomized, double-blind, placebo-controlled human trial.
Product relevance
Ingredient evidence for ubiquinone, the oxidized form of CoQ10. The trial did not test the DR.MORGAN formula.
Sample or population
24 participants in the ubiquinone group and 25 in the control group met inclusion criteria.
Studied dose
400 mg/day of ubiquinone or placebo.
Duration
12 weeks.
Finding
The authors reported differences in neuropathy scores, selected nerve-conduction measures and lipid peroxidation. The nerve growth factor measure did not change. No drug-related adverse reactions were reported.
Limitations
This small clinical study used a different intervention and a specific patient population. The findings do not establish a use for the retail formula in diabetes or neuropathy.
Study quality
Placebo-controlled design with clinical scores, nerve tests and biomarkers. Editorial review was limited to the abstract. No formal risk-of-bias rating was assigned.
Funding and disclosures
Funding and conflicts were not verified from the abstract.

Related products

Dr. Morgan PQQ + CoQ10, 60 vegetarian capsules, NPN 80151407

PQQ + CoQ10

$39.00 CAD

View product

Safety and precautions

Follow the warnings and directions for the relevant product. Research using a different form, formulation or study dose does not determine the safety of this combination.

References

  1. Ho et al. · 2020 · Antioxidants (Basel) · PMID 32899227
  2. Mieszkowski et al. · 2024 · Antioxidants (Basel) · PMID 39061829
  3. Gül et al. · 2011 · PMID 21681167
  4. Laaksonen et al. · 1995 · Eur J Appl Physiol Occup Physiol · PMID 8789577
  5. Henriksen et al. · 1999 · Diabet Med · PMID 10220205
  6. Hernández-Ojeda et al. · 2012 · J Diabetes Complications · PMID 22595020
  7. PQQ + CoQ10 licence

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