Evidence / Ishimoto et al. · 2024
Ergothioneine and TrkB signalling
Selected research. Study type, product relevance and limitations are shown separately.
Editorial study summary
- Study type
- Mouse experiments and an exploratory human biomarker comparison.
- Product relevance
- Mechanistic evidence with a human biomarker component.
- Sample or population
- Mice and human volunteers. Counts are not reported in the abstract.
- Studied dose
- Mice received diets with differing ergothioneine content. Volunteers received ergothioneine tablets or placebo. Amounts are not reported in the abstract.
- Duration
- Not reported in the abstract.
- Finding
- In mice, inhibiting TrkB blocked changes seen after restoring dietary ergothioneine. In volunteers, a serum vesicle marker of TrkB phosphorylation was higher with ergothioneine and correlated with several cognitive scores.
- Limitations
- The human biomarker correlations do not establish a cognitive benefit. Key human design details are missing from the abstract.
- Study quality
- Mechanistic animal experiments paired with exploratory human measurements. Editorial review was limited to the abstract. No formal risk-of-bias rating was assigned.
- Funding and disclosures
- The PubMed disclosure states that the authors declared no competing interests. Funding was not verified.
The studies discussed here examine ingredients or other formulations. They do not establish results for this DR.MORGAN finished product.