Ergothioneine, MPST and mitochondria

Editorial study summary

Study type

Mechanistic laboratory and mouse experiments.

Product relevance

Direct molecular-target evidence in experimental models.

Sample or population

Mouse and laboratory models. Counts are not reported in the abstract.

Studied dose

Not reported in the abstract.

Duration

Not reported in the abstract.

Finding

Ergothioneine bound to and activated MPST. The authors linked this pathway to mitochondrial respiration and exercise-training performance in mice.

Limitations

No human exercise trial is described. The molecular findings cannot predict human outcomes.

Study quality

Proteome-wide target identification and experimental validation. Editorial review was limited to the abstract. No formal risk-of-bias rating was assigned.

Funding and disclosures

The PubMed disclosure lists commercial founding, equity and board roles for several authors. Funding was not verified.

The studies discussed here examine ingredients or other formulations. They do not establish results for this DR.MORGAN finished product.

Reference

1. Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST. Cell Metab. 2025. DOI 10.1016/j.cmet.2025.01.024. PMID 39965563