An S-equol trial in Japanese women

Editorial study summary

Study type

Randomized, double-blind, placebo-controlled human trial.

Product relevance

Ingredient evidence from a different equol preparation.

Sample or population

134 Japanese women aged 40–59 were randomized and 127 completed the study.

Studied dose

Placebo, 10 mg once daily or 10 mg three times daily.

Duration

12 weeks.

Finding

Several mood scores differed from placebo at the higher dose. Other reported changes were from baseline in perimenopausal or postmenopausal equol non-producers. One participant in the higher-dose group reported a systemic rash.

Limitations

Selected analyses and a different preparation limit application to other populations and formulas.

Study quality

Placebo-controlled design with multiple symptom and mood measures. Editorial review was limited to the abstract. No formal risk-of-bias rating was assigned.

Funding and disclosures

Funding and conflicts were not verified from the abstract.

The studies discussed here examine ingredients or other formulations. They do not establish results for this DR.MORGAN finished product.

Reference

1. New equol supplement for relieving menopausal symptoms: randomized, placebo-controlled trial of Japanese women. Menopause. 2009. DOI 10.1097/gme.0b013e31818379fa. PMID 19131846