S-equol and bone-related measures

Editorial study summary

Study type

Randomized, double-blind, placebo-controlled human pilot.

Product relevance

Ingredient evidence from a different natural S-equol preparation.

Sample or population

93 postmenopausal Japanese equol non-producers.

Studied dose

Placebo or 2, 6 or 10 mg/day of equol.

Duration

1 year.

Finding

The highest dose differed from placebo on a urinary bone-resorption marker. The authors also report preservation of whole-body bone mineral density. Serum sex and thyroid hormone concentrations did not differ among groups.

Limitations

The abstract does not report fracture outcomes. This population and preparation limit generalization.

Study quality

Placebo-controlled pilot with bone-related and hormonal measures. Editorial review was limited to the abstract. No formal risk-of-bias rating was assigned.

Funding and disclosures

Funding and conflicts were not verified from the abstract.

The studies discussed here examine ingredients or other formulations. They do not establish results for this DR.MORGAN finished product.

Reference

1. Natural S-equol decreases bone resorption in postmenopausal, non-equol-producing Japanese women: a pilot randomized, placebo-controlled trial. Menopause. 2011. DOI 10.1097/gme.0b013e3181f85aa7. PMID 21252728