Cardiac measures in animal models and dietary associations

Editorial study summary

Study type

Mouse and rat experiments with human dietary observations.

Product relevance

Mechanistic animal evidence plus a separate human dietary association.

Sample or population

Mice, salt-sensitive rats and human dietary data. Counts are not reported in the abstract.

Studied dose

Not reported in the abstract.

Duration

Not reported in the abstract.

Finding

Several cardiac measures changed in rodents. The cardiac effect was absent in mice lacking cardiomyocyte Atg5. Higher estimated human food intake correlated with lower blood pressure and cardiovascular disease incidence.

Limitations

The human component did not assign spermidine. Rodent findings and dietary correlations cannot establish cardiovascular benefit in people.

Study quality

Animal experiments included a test of autophagy dependence. Editorial review was limited to the abstract. No formal risk-of-bias rating was assigned.

Funding and disclosures

The PubMed disclosure lists equity interests in a natural-extract company for several authors. Funding was not verified.

The studies discussed here examine ingredients or other formulations. They do not establish results for this DR.MORGAN finished product.

Reference

1. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 2016. DOI 10.1038/nm.4222. PMID 27841876