Evidence / Schwarz et al. · 2018
Short-term tolerability of a spermidine-rich extract
Selected research. Study type, product relevance and limitations are shown separately.
Editorial study summary
- Study type
- Randomized, double-blind, placebo-controlled human safety study, with a separate repeated-dose mouse toxicity study.
- Product relevance
- Relevant ingredient safety evidence for the specific wheat germ extract and dose.
- Sample or population
- Human study: 30 adults aged 60–80 years with subjective cognitive decline. A separate preclinical component used mice.
- Studied dose
- Human study: a spermidine-rich wheat germ extract providing 1.2 mg/day of spermidine, or placebo.
- Duration
- Human study: 3 months. Mouse repeated-dose study: 28 days.
- Finding
- The human groups showed no differences in the reported vital signs, weight, clinical chemistry, blood safety measures or self-reported health. Adherence exceeded 85%. The separate mouse study reported no increase in the monitored toxicity findings.
- Limitations
- The human sample was small and follow-up was short. The results apply to the studied extract and dose and cannot establish safety for other formulations or long-term use.
- Study quality
- The PubMed abstract was reviewed. This trial examined safety and tolerability. No formal risk-of-bias rating was assigned.
- Funding and disclosures
- PubMed indexes Austrian Science Fund (FWF) support. Competing interests were not verified from the approved source material.
The studies discussed here examine ingredients or other formulations. They do not establish results for this DR.MORGAN finished product.