Dietary spermidine and MRI measures

Editorial study summary

Study type

Exploratory cross-sectional human dietary study.

Product relevance

Indirect evidence from questionnaire estimates of food intake.

Sample or population

90 older adults with subjective cognitive decline and 47 controls.

Studied dose

Usual dietary intake estimated by questionnaire. No assigned dose.

Duration

No follow-up period is reported in the abstract.

Finding

Higher estimated intake was associated with several MRI measures, including hippocampal volume. The associations did not significantly differ by participant group.

Limitations

MRI associations and self-reported food intake cannot establish causation or supplement effects.

Study quality

Exploratory regression analyses with structural imaging. Editorial review was limited to the abstract. No formal risk-of-bias rating was assigned.

Funding and disclosures

One author disclosed consulting fees, honoraria and royalties in the PubMed record. Funding was not verified.

The studies discussed here examine ingredients or other formulations. They do not establish results for this DR.MORGAN finished product.

Reference

1. Spermidine intake is associated with cortical thickness and hippocampal volume in older adults. Neuroimage. 2020. DOI 10.1016/j.neuroimage.2020.117132. PMID 32629145