Dietary spermidine, cognition and experimental models

Editorial study summary

Study type

Mouse and fruit-fly experiments plus prospective human dietary data.

Product relevance

Indirect human dietary association and separate preclinical mechanisms.

Sample or population

Mice, fruit flies and a human cohort. Counts are not reported in the abstract.

Studied dose

Not reported in the abstract. The human component assessed dietary intake.

Duration

Not reported in the abstract.

Finding

Animal experiments linked feeding to mitochondrial and learning measures. Higher estimated human dietary intake was associated with lower risk of cognitive impairment.

Limitations

Human data were observational. Feeding effects in animals do not establish a human supplement effect.

Study quality

Multiple experimental models plus a prospective human association. Editorial review was limited to the abstract. No formal risk-of-bias rating was assigned.

Funding and disclosures

The PubMed disclosure lists commercial equity, consultancy, research contracts and a related pending patent for some authors. Funding was not verified.

The studies discussed here examine ingredients or other formulations. They do not establish results for this DR.MORGAN finished product.

Reference

1. Dietary spermidine improves cognitive function. Cell Rep. 2021. DOI 10.1016/j.celrep.2021.108985. PMID 33852843